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Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

Authors :
Edurne Rujas
Iga Kucharska
Yong Zi Tan
Samir Benlekbir
Hong Cui
Tiantian Zhao
Gregory A. Wasney
Patrick Budylowski
Furkan Guvenc
Jocelyn C. Newton
Taylor Sicard
Anthony Semesi
Krithika Muthuraman
Amy Nouanesengsy
Clare Burn Aschner
Katherine Prieto
Stephanie A. Bueler
Sawsan Youssef
Sindy Liao-Chan
Jacob Glanville
Natasha Christie-Holmes
Samira Mubareka
Scott D. Gray-Owen
John L. Rubinstein
Bebhinn Treanor
Jean-Philippe Julien
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Here, the authors combine three different antibody specificities and an Fc domain on a single multivalent molecule, resulting in high neutralization activity despite viral sequence variability.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.21239c53aca444dbbc85f54151271ca5
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-23825-2