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Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection

Authors :
Alessandra Sacchi
Germana Grassi
Stefania Notari
Simona Gili
Veronica Bordoni
Eleonora Tartaglia
Rita Casetti
Eleonora Cimini
Davide Mariotti
Gabriele Garotto
Alessia Beccacece
Luisa Marchioni
Michele Bibas
Emanuele Nicastri
Giuseppe Ippolito
Chiara Agrati
Source :
Cells, Vol 10, Iss 8, p 2111 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Massive platelet activation and thrombotic events characterize severe COVID-19, highlighting their critical role in SARS-CoV-2-induced immunopathology. Since there is a well-described expansion of myeloid-derived suppressor cells (MDSC) in severe COVID-19, we evaluated their possible role in platelet activation during SARS-CoV-2 infection. During COVID-19, a lower plasmatic L-arginine level was observed compared to healthy donors, which correlated with MDSC frequency. Additionally, activated GPIIb/IIIa complex (PAC-1) expression was higher on platelets from severe COVID-19 patients compared to healthy controls and inversely correlated with L-arginine plasmatic concentration. Notably, MDSC were able to induce PAC-1 expression in vitro by reducing L-arginine concentration, indicating a direct role of PMN-MDSC in platelet activation. Accordingly, we found a positive correlation between ex vivo platelet PAC-1 expression and PMN-MDSC frequency. Overall, our data demonstrate the involvement of PMN-MDSC in triggering platelet activation during COVID-19, highlighting a novel role of MDSC in driving COVID-19 pathogenesis.

Details

Language :
English
ISSN :
20734409
Volume :
10
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.218f0a080f1b402ea189986c93854094
Document Type :
article
Full Text :
https://doi.org/10.3390/cells10082111