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Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications

Authors :
Menéndez-González Manuel
Bogdan-Ionel Tamba
Maxime Leclere
Mostafa Mabrouk
Thomas-Gabriel Schreiner
Romeo Ciobanu
Tomás-Zapico Cristina
Source :
Pharmaceutics, Vol 15, Iss 3, p 768 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Intrathecal pseudodelivery of drugs is a novel route to administer medications to treat neurodegenerative diseases based on the CSF-sink therapeutic strategy by means of implantable devices. While the development of this therapy is still in the preclinical stage, it offers promising advantages over traditional routes of drug delivery. In this paper, we describe the rationale of this system and provide a technical report on the mechanism of action, that relies on the use of nanoporous membranes enabling selective molecular permeability. On one side, the membranes do not permit the crossing of certain drugs; whereas, on the other side, they permit the crossing of target molecules present in the CSF. Target molecules, by binding drugs inside the system, are retained or cleaved and subsequently eliminated from the central nervous system. Finally, we provide a list of potential indications, the respective molecular targets, and the proposed therapeutic agents.

Details

Language :
English
ISSN :
15030768, 19994923, and 21988781
Volume :
15
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.21988781a83d4e678aa64d3dc4e2f24f
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics15030768