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TNIK signaling imprints CD8+ T cell memory formation early after priming

Authors :
Carla A. Jaeger-Ruckstuhl
Magdalena Hinterbrandner
Sabine Höpner
Colin E. Correnti
Ursina Lüthi
Olivier Friedli
Stefan Freigang
Mohamad F. Al Sayed
Elias D. Bührer
Michael A. Amrein
Christian M. Schürch
Ramin Radpour
Carsten Riether
Adrian F. Ochsenbein
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Coordinate expression of multiple factors play critical roles in the regulation between effector and memory CD8+ T cell differentiation. Here the authors show upon acute viral infection TNIK is critically required as a regulator of effector and memory T cell differentiation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.21c39ff478914e4584620912b78764da
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-15413-7