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Contribution of Cholesterol and Oxysterols in the Physiopathology of Cataract: Implication for the Development of Pharmacological Treatments
- Source :
- Journal of Ophthalmology, Vol 2011 (2011)
- Publication Year :
- 2011
- Publisher :
- Hindawi Limited, 2011.
-
Abstract
- The development of cataract is associated with some lipid changes in human lens fibers, especially with increased accumulation and redistribution of cholesterol inside these cells. Some direct and indirect lines of evidence, also suggest an involvement of cholesterol oxide derivatives (also named oxysterols) in the development of cataract. Oxysterol formation can result either from nonenzymatic or enzymatic processes, and some oxysterols can induce a wide range of cytotoxic effects (overproduction of reactive oxygen species (ROS); phospholipidosis) which might contribute to the initiation and progression of cataract. Thus, the conception of molecules capable of regulating cholesterol homeostasia and oxysterol levels in human lens fibers can have some interests and constitute an alternative to surgery at least at early stages of the disease.
- Subjects :
- Ophthalmology
RE1-994
Subjects
Details
- Language :
- English
- ISSN :
- 2090004X and 20900058
- Volume :
- 2011
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.22008a833c7a412e925065b88da26a02
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2011/471947