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Antitumour Activity of Dehydroxymethylepoxyquinomycin (DHMEQ): a Literature Review
- Source :
- Креативная хирургия и онкология, Vol 11, Iss 1, Pp 68-75 (2021)
- Publication Year :
- 2021
- Publisher :
- Bashkir State Medical University, 2021.
-
Abstract
- Carcinogenesis research uncovers new pathogenesis links as vulnerable targets of effective antitumour therapies. Among the key mediators of immune response, cell proliferation, cell apoptosis and inflammation is transcription factor NF-κB. Misregulation of an NF-κB-dependent pathway is found in solid and haematopoietic tumour cells. One of the best known NF-κB functions is expression regulation of genes involved in the apoptosis inhibition or activation and survival in both intact and malignant cells. The NF-κB-mediated pathways’ involvement in carcinogenesis, angiogenesis and tumour resistance to chemo- and radiotherapies makes this factor a promising target for drug anti-cancer interventions. This review summarises evidence on the antitumour and anti-inflammatory activity of a high-potent and specific low molecular-weight NF-κB inhibitor, dehydroxymethylhepoxyquinomycin (DHMEQ), as a candidate therapeutic agent in treatment for variant malignancies.
Details
- Language :
- English, Russian
- ISSN :
- 23070501 and 20763093
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Креативная хирургия и онкология
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.225ac206c74c6687b51d44d931fa18
- Document Type :
- article
- Full Text :
- https://doi.org/10.24060/2076-3093-2021-11-1-68-75