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The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory Animals

Authors :
A. U. Sabitov
L. P. Larionov
M. N. Dobrinskaya
O. V. Ledyankina
A. V. Osipenko
I. E. Valamina
E. V. Philippova
I. M. Fatikhov
Source :
Антибиотики и Химиотерапия, Vol 68, Iss 5-6, Pp 24-32 (2023)
Publication Year :
2023
Publisher :
LLC "Publishing House OKI", 2023.

Abstract

The paper presents the results of extended preclinical studies demonstrating the safety using the direct-acting antiviral drug Riamilovir in immature white rats. Riamilovir did not show any toxic effects on the growth of animals, their fertility, behavior, hematological and biochemical parameters, as well as morphology of visceral organs when used in a course. According to the results of the studies, Ramilovir can be recommended for multicenter clinical trials in adolescents and children of younger age groups.

Details

Language :
Russian
ISSN :
02352990
Volume :
68
Issue :
5-6
Database :
Directory of Open Access Journals
Journal :
Антибиотики и Химиотерапия
Publication Type :
Academic Journal
Accession number :
edsdoj.227b867a61814c83a2f248ac31400cfe
Document Type :
article
Full Text :
https://doi.org/10.37489/0235-2990-2023-68-5-6-24-32