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A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies

Authors :
Gianluca Sambataro
Chiara Alfia Ferrara
Carla Spadaro
Sebastiano Emanuele Torrisi
Giovanna Vignigni
Ada Vancheri
Giuseppe Muscato
Nicoletta Del Papa
Michele Colaci
Lorenzo Malatino
Stefano Palmucci
Lorenzo Cavagna
Giovanni Zanframundo
Francesco Ferro
Chiara Baldini
Domenico Sambataro
Carlo Vancheri
Source :
Diagnostics, Vol 12, Iss 5, p 1139 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

In this study, it was found that myositis-specific and myositis-associated antibodies (MSAs and MAAs) improved the recognition of idiopathic inflammatory myopathies (IIMs) in interstitial lung disease (ILD) patients. The objective of this study is to propose a clinical method to evaluate myalgia in respiratory settings as a possible tool for the recognition of MSA/MAA positivity in ILD patients. We prospectively enrolled 167 ILD patients with suspected myositis, of which 63 had myalgia evoked at specific points (M+ILD+). We also enrolled in a 174 patients with only myalgia (M+ILD-) in a rheumatological setting. The patients were assessed jointly by rheumatologists and pulmonologists and were tested for autoantibodies. M+ILD+ patients were positive for at least one MAA/MSA in 68.3% of cases, as were M-ILD+ patients in 48.1% of cases and M+ILD- patients in 17.2% of cases (p = 0.01 and p = 0.02). Myalgia was significantly associated with positivity for MSA/MAAs in ILD patients (p = 0.01, X2: 6.47). In conclusion, myalgia in ILD patients with suspected myositis is associated with MSA/MAA positivity, and could support a diagnosis of IIM. A significant proportion of M+ILD- patients also had MSA/MAA positivity, a phenomenon warranting further study to evaluate its clinical meaning.

Details

Language :
English
ISSN :
20754418
Volume :
12
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Diagnostics
Publication Type :
Academic Journal
Accession number :
edsdoj.2296313f9954405883d7c1b5871e776
Document Type :
article
Full Text :
https://doi.org/10.3390/diagnostics12051139