Back to Search
Start Over
Serum concentrations of complement C3 and C4 in dogs with idiopathic epilepsy
- Source :
- Journal of Veterinary Internal Medicine, Vol 38, Iss 2, Pp 1074-1082 (2024)
- Publication Year :
- 2024
- Publisher :
- Wiley, 2024.
-
Abstract
- Abstract Background High concentrations of complement factors are presented in serum of animal epilepsy models and human patients with epilepsy. Objectives To determine whether complement dysregulation occurs in dogs with idiopathic epilepsy (IE). Animals The study included 49 dogs with IE subgrouped into treatment (n = 19), and nontreatment (n = 30), and 29 healthy dogs. Methods In this case‐control study, the serum concentrations of the third (C3) and fourth (C4) components of the complement system were measured using a canine‐specific ELISA kit. Results Serum C3 and C4 concentrations were significantly higher in dogs with IE (C3, median; 4.901 [IQR; 3.915‐6.673] mg/mL, P 3 times/month had significantly higher serum C3 (6.461 [4.695‐8.735] mg/mL; P
- Subjects :
- biomarker
classical pathway
neuroinflammation
seizure
Veterinary medicine
SF600-1100
Subjects
Details
- Language :
- English
- ISSN :
- 19391676 and 08916640
- Volume :
- 38
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Veterinary Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.22a0588c78904808943bd49f528e2cc0
- Document Type :
- article
- Full Text :
- https://doi.org/10.1111/jvim.17008