Back to Search Start Over

Ameliorative effect of total ginsenosides from heat-treated fresh ginseng against cyclophosphamide-induced liver injury in mice

Ameliorative effect of total ginsenosides from heat-treated fresh ginseng against cyclophosphamide-induced liver injury in mice

Authors :
Ping Tang
Guangquan Ren
Hongyang Zou
Sitong Liu
Junshun Zhang
Zhiyi Ai
Yue Hu
Linlin Cui
Bo Nan
Zhicheng Zhang
Yuhua Wang
Source :
Current Research in Food Science, Vol 8, Iss , Pp 100734- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

This study evaluated the effect of heat treatment on the conversion of ginsenoside and the ameliorative effect of heat-treated total ginsenoside (HG) from fresh ginseng on cyclophosphamide (CTX)-induced liver injury. LC-MS analysis revealed that the content of rare ginsenosides increased markedly after heat treatment. HG significantly attenuated CTX-induced hepatic histopathological injury in mice. Western blotting analysis showed that untreated total ginsenoside (UG) and HG regulated the Nrf2/HO-1 and TLR4/MAPK pathways. Importantly, these results may be relevant to the modulation of the intestinal flora. UG and HG significantly increased the short-chain fatty acids (SCFAs)-producing bacteria Lactobacillus and reduced the LPS-producing bacteria Bacteroides and Parabacteroides. These changes in intestinal flora affected the levels of TNF-α, LPS and SCFAs. In short, UG and HG alleviated CTX-induced liver injury by regulating the intestinal flora and the LPS-TLR4-MAPK pathway, and HG was more effective. HG has the potential to be a functional food that can alleviate chemical liver injury.

Details

Language :
English
ISSN :
26659271
Volume :
8
Issue :
100734-
Database :
Directory of Open Access Journals
Journal :
Current Research in Food Science
Publication Type :
Academic Journal
Accession number :
edsdoj.22c86d0513e423ab1f67768ec396210
Document Type :
article
Full Text :
https://doi.org/10.1016/j.crfs.2024.100734