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Recent Advances in Omics, Computational Models, and Advanced Screening Methods for Drug Safety and Efficacy

Authors :
Ahrum Son
Jongham Park
Woojin Kim
Yoonki Yoon
Sangwoon Lee
Jaeho Ji
Hyunsoo Kim
Source :
Toxics, Vol 12, Iss 11, p 822 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

It is imperative to comprehend the mechanisms that underlie drug toxicity in order to enhance the efficacy and safety of novel therapeutic agents. The capacity to identify molecular pathways that contribute to drug-induced toxicity has been significantly enhanced by recent developments in omics technologies, such as transcriptomics, proteomics, and metabolomics. This has enabled the early identification of potential adverse effects. These insights are further enhanced by computational tools, including quantitative structure–activity relationship (QSAR) analyses and machine learning models, which accurately predict toxicity endpoints. Additionally, technologies such as physiologically based pharmacokinetic (PBPK) modeling and micro-physiological systems (MPS) provide more precise preclinical-to-clinical translation, thereby improving drug safety assessments. This review emphasizes the synergy between sophisticated screening technologies, in silico modeling, and omics data, emphasizing their roles in reducing late-stage drug development failures. Challenges persist in the integration of a variety of data types and the interpretation of intricate biological interactions, despite the progress that has been made. The development of standardized methodologies that further enhance predictive toxicology is contingent upon the ongoing collaboration between researchers, clinicians, and regulatory bodies. This collaboration ensures the development of therapeutic pharmaceuticals that are more effective and safer.

Details

Language :
English
ISSN :
23056304
Volume :
12
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Toxics
Publication Type :
Academic Journal
Accession number :
edsdoj.22ed6a43989442dba485e0566054590b
Document Type :
article
Full Text :
https://doi.org/10.3390/toxics12110822