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Human brain mapping using co-registered fUS, fMRI and ESM during awake brain surgeries: A proof-of-concept study
- Source :
- NeuroImage, Vol 283, Iss , Pp 120435- (2023)
- Publication Year :
- 2023
- Publisher :
- Elsevier, 2023.
-
Abstract
- Accurate, depth-resolved functional imaging is key in both understanding and treatment of the human brain. A new sonography-based imaging technique named functional Ultrasound (fUS) uniquely combines high sensitivity with submillimeter-subsecond spatiotemporal resolution available in large fields-of-view. In this proof-of-concept study we show that: (A) fUS reveals the same eloquent regions as found by fMRI while concomitantly visualizing in-vivo microvascular morphology underlying these functional hemodynamics and (B) fUS-based functional maps are confirmed by Electrocortical Stimulation Mapping (ESM), the current gold-standard in awake neurosurgical practice. This unique cross-modality experiment was performed using motor, visual and language-related functional tasks in patients undergoing awake brain tumor resection. The current work serves as an important milestone towards further maturity of fUS as well as a novel avenue to increase our understanding of hemodynamics-based functional brain imaging.
Details
- Language :
- English
- ISSN :
- 10959572
- Volume :
- 283
- Issue :
- 120435-
- Database :
- Directory of Open Access Journals
- Journal :
- NeuroImage
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.22f785f4c334735aa1d580b24bb8ae5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.neuroimage.2023.120435