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Mendelian randomisation analysis for intestinal disease: achievement and future

Authors :
Jie Chen
Xue Li
Xiaoyan Wang
Shuai Yuan
Yuhao Sun
Xixian Ruan
Tianyi Che
Xuejie Chen
Tian Fu
Source :
eGastroenterology, Vol 2, Iss 2 (2024)
Publication Year :
2024
Publisher :
BMJ Publishing Group, 2024.

Abstract

Intestinal disease is a group of complex digestive system diseases imposing a significant burden globally. Identifying the risk factors and potential complications of intestinal disease is important for its prevention and treatment. However, traditional observational clinical studies are limited by confounding factors and reverse causation, making causal inference challenging. Mendelian randomisation (MR) method has been developed to effectively mitigate these constraints and assess the causal relationships. This review briefly introduces the MR method, summarises MR research on intestinal disease and delineates the prospective avenues for future research. Conventional risk factors, such as lifestyle behaviours (eg, physical activity, smoking and alcohol consumption), nutrients (eg, selenium), obesity markers (eg, body mass index and waist-to-hip ratio) and inflammatory biomarkers, have been validated in MR studies. Multiomics MR studies are becoming novel hotspots, which provide a theoretical foundation for the exploration of pathogenesis and the investigation of new drug targets. However, most of the recent studies are based on European individuals, and thus it is necessary to replicate the results in other ancestries. Moreover, triangulation integrating MR and other epidemiology methods is suggested as a validated paradigm for causal inference in future MR studies.

Details

Language :
English
ISSN :
27660125 and 29767296
Volume :
2
Issue :
2
Database :
Directory of Open Access Journals
Journal :
eGastroenterology
Publication Type :
Academic Journal
Accession number :
edsdoj.23017266312048719045fba72c2cffda
Document Type :
article
Full Text :
https://doi.org/10.1136/egastro-2023-100058