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Cell cycle checkpoint revolution: targeted therapies in the fight against malignant tumors

Authors :
Guangming Song
Jue Liu
Xing Tang
Jie Zhong
Yuhuan Zeng
Xiaodi Zhang
Jianbin Zhou
Jie Zhou
Lu Cao
Qunfeng Zhang
Yukun Li
Source :
Frontiers in Pharmacology, Vol 15 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Malignant tumors are among the most important causes of death worldwide. The pathogenesis of a malignant tumor is complex and has not been fully elucidated. Studies have shown that such pathogenesis is related to abnormal cell cycle progression. The expression levels of cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors as well as functions of the cell cycle checkpoints determine whether the cell cycle progression is smooth. Cell-cycle-targeting drugs have the advantages of high specificity, low toxicity, low side effects, and low drug resistance. Identifying drugs that target the cell cycle and applying them in clinical treatments are expected to promote chemotherapeutic developments against malignant tumors. This article aims to review drugs targeted against the cell cycle and their action mechanisms.

Details

Language :
English
ISSN :
16639812
Volume :
15
Database :
Directory of Open Access Journals
Journal :
Frontiers in Pharmacology
Publication Type :
Academic Journal
Accession number :
edsdoj.234b1024b35430ca8c81b6cfe905c71
Document Type :
article
Full Text :
https://doi.org/10.3389/fphar.2024.1459057