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Association of the TNF-α -308G/A polymorphism with lipid profile changes in response to aerobic training program
- Source :
- Biology of Sport, Vol 36, Iss 3, Pp 291-296 (2019)
- Publication Year :
- 2019
- Publisher :
- Termedia Publishing House, 2019.
-
Abstract
- Promoter polymorphism of the tumor necrosis factor-α (TNF-α) gene is associated with obesityrelated traits, although the role of its potential modifying effect on changes in obesity-related parameters achieved through a training program is still unknown. The aim of the present study was to examine whether the TNF-α-308G/A polymorphism (rs1800629) influences the effects of a training program. Accordingly, we studied the alleles and genotypes distribution in a group of 168 Polish Caucasian women measured for selected body mass and composition, as well as biochemical parameters before and after the realization of a 12-week aerobic training program. Our results showed that TNF-α genotypes can modulate training-induced biochemical parameter changes such as lipid profile. We demonstrated that carriers of the GG genotype are associated with decreases in post-training high-density lipoprotein cholesterol (HDL-C) levels (p
Details
- Language :
- English
- ISSN :
- 0860021X and 20831862
- Volume :
- 36
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Biology of Sport
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.235ff69650ef4b9cab3c0ba2eedfd148
- Document Type :
- article
- Full Text :
- https://doi.org/10.5114/biolsport.2019.85456