Back to Search
Start Over
Maltase and sucrase inhibitory activities and hypoglycemic effects of carbon dots derived from charred Fructus crataegi
- Source :
- Materials Research Express, Vol 6, Iss 12, p 125005 (2019)
- Publication Year :
- 2019
- Publisher :
- IOP Publishing, 2019.
-
Abstract
- Although carbon dots (CDs) have been widely applied in nanobiotechnology and biomedicine, few studies have evaluated the intrinsic self-bioactivities and no reports have described the disaccharidase inhibitory activities of CDs. In this study, charred Fructus crataegi -derived CDs (CFC-CDs) having an average diameter of 1.3–5.6 nm are developed, without further modifications. Owing to an abundance of surface groups, CFC-CDs show distinct solubility, biocompatibility, and bioactivity. Moreover, CFC-CDs inhibit the catalytic activities of sucrase and maltase in vitro and reduce postprandial blood glucose levels in vivo , possibly by acting as a disaccharidase inhibitor. This discovery provides guidance for further research on the bioactivities of CDs and supports their potential applications in the biomedical and healthcare fields.
Details
- Language :
- English
- ISSN :
- 20531591
- Volume :
- 6
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Materials Research Express
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.236c6b7d2ab348d390a6141921836468
- Document Type :
- article
- Full Text :
- https://doi.org/10.1088/2053-1591/ab4fd8