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Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler

Authors :
Brieuc Van Nieuwenhuyse
Dimitri Van der Linden
Olga Chatzis
Cédric Lood
Jeroen Wagemans
Rob Lavigne
Kaat Schroven
Jan Paeshuyse
Catherine de Magnée
Etienne Sokal
Xavier Stéphenne
Isabelle Scheers
Hector Rodriguez-Villalobos
Sarah Djebara
Maya Merabishvili
Patrick Soentjens
Jean-Paul Pirnay
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

In this study, authors use combinatory bacteriophage-antibiotic therapy, as treatment for extensively drug-resistant Pseudomonas aeruginosa infection in a toddler post liver transplantation. They report on the clinical and microbiological improvement, and present their investigation on how bacterial phage resistance did not result in therapeutic failure.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.23851cad07104241a991b0c91d689908
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-33294-w