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The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex
- Source :
- Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- The formation of the mitotic checkpoint complex requires an intricate spatial coordination amongst the proteins Bub1, Mad1, Cdc20, and Mad2. Chen et al show that a structural flexibility in Mad1 plays an essential role in achieving this coordination.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.238c71302b0460b962ca812a2e41935
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-023-37235-z