Cancer treatment delays among cancer patients living with HIV during the COVID‐19 pandemic in the United States

Abstract Background The COVID‐19 pandemic led to care disruptions across the cancer continuum. It is unknown if immunosuppressed patients with cancer, who may be at higher risk for complications of SARS‐CoV‐2 infection, are disproportionately impacted. Thus, we aimed to compare delays in cancer treatment initiation between people living with HIV (PLWH) and cancer, the general cancer population (GCP), and patients with cancer and a history of solid organ transplant (SOT). Comparisons were made across the period 2 years preceding the pandemic versus the first year of the pandemic. Methods We used data from a real‐world electronic health record‐derived de‐identified database (2018–2021) comprised of US patients with cancer from 800 sites of care across the country. We included patients with 19 different cancer types. We calculated time to cancer treatment initiation (TTI) as the difference between the date of cancer diagnosis and the earliest date that cancer treatment was recorded. Results The sample included 181 PLWH, 65,073 GCP patients, and 195 patients with a SOT. Difference‐in‐difference regression models adjusted for age, sex, and presence of metastatic disease at cancer diagnosis revealed a significant increase in delayed TTI among PLWH compared to the GCP during COVID‐19 versus prior to COVID‐19, with delays increasing by approximately 1 month during the pandemic (DID: 32.6 days [8.9–56.3]; p = 0.007). The increase in TTI for PLWH was observed across treatment modalities, including surgery (DID: 55.1 [28.8–81.3], p