Assessment of the relationship between serum uric acid and glucose levels in healthy, prediabetic and diabetic individuals

Abstract Background In epidemiological studies, serum uric acid (SUA) has been shown to be associated with hypertension and cardiovascular disorders. However, limited studies have evaluated the relationship between SUA and glucose levels in healthy and diabetic individuals and their observed findings are inconsistent. This study aimed to examine the relationship between SUA and fasting blood glucose (FBG) levels among healthy, prediabetic and diabetic individuals in Bangladesh. Methods In total, 310 blood samples were collected from 215 male and 95 female subjects and analyzed for FBG, SUA, and lipid levels. All participants were categorized into four quartiles based on SUA concentrations. Diabetes and prediabetes were defined as FBG level ≥ 126 mg/dL and 100–125 mg/dL, respectively. The association between SUA and diabetes was evaluated by multinomial logistic regression analysis. Results The prediabetic and diabetic individuals had a lower mean level of SUA (338.2 ± 101.6 and 290.9 ± 98.2 µmol/L, respectively) compared to healthy (369.5 ± 110.9 µmol/L) individuals (p