Factors influencing vancomycin trough concentration in burn patients: a single center retrospective study

ObjectiveTo analyze factors influencing the vancomycin trough concentration in burn patients to provide a basis for the more rational use of vancomycin in these patients.Materials and methodsWe collected the clinical data of adult burn patients treated with vancomycin in a Chinese hospital. Vancomycin was administered at a dosing regimen of 1.0 g q12 h. Patients were divided into a therapeutic group with vancomycin trough concentration in the target therapeutic range (10–20 μg/mL) and a subtherapeutic group with vancomycin trough concentration in the subtherapeutic range (