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Minor histocompatibility antigens represented in HLA-A*02:01 and their search strategies
- Source :
- Онкогематология, Vol 18, Iss 3, Pp 115-124 (2023)
- Publication Year :
- 2023
- Publisher :
- ABV-press, 2023.
-
Abstract
- Minor histocompatibility antigens (MiHAs) are polymorphic peptides on the cell surface derived from self-proteins that are capable to induce an immune response during allogeneic hematopoietic stem cells transplantation. Their presentation occurs in the context of the certain major histocompatibility complex (HLA – human leucocyte antigen) alleles. One of the most common HLA alleles is HLA-A*02:01. Accordingly, for a significant number of donors and recipients pairs, it is possible to use the MiHAs presented in the HLA-A*02:01 as a target for relapsed leukemia therapy. This review discusses the main known MiHAs presented in the context of HLA-A*02:01, their characteristics and approaches used for identification. The described approaches may be used to search for new MiHAs for immunotherapy.
Details
- Language :
- Russian
- ISSN :
- 18188346 and 24134023
- Volume :
- 18
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Онкогематология
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.247377f3ac06414a8f31c97045ff8940
- Document Type :
- article
- Full Text :
- https://doi.org/10.17650/1818-8346-2023-18-3-115-124