THE EFFECT OF (DMAA), DIMETHYLACETAMIDE ON THE BLOOD OF THE COWS IN VITRO

Authors :: H. H. AL-Attia
Y. M. Jasim
Source :: The Iraqi Journal of Veterinary Medicine, Vol 12, Iss 1 (1988)
Publication Year :: 1988
Publisher :: University of Baghdad, College of Veterinary Medicine, 1988.
Abstract: Dimethylacetamide (DMMA) is used as a solvent for drug preparations, DMAA and its metabolites Monome thy lacetamide (MMAA) and acetamide (AA) cause hemolysis in concentrations above 100 (DMAA), 44 (MMAA) and 40 (AA) mg/ml blood respectively. The effects are double to three times stronger than after distilled water. Dimethylation in the animal body after treatment is followed by an increase of the hemolytic activity. Concentrations after therapeutic use in vivo are as high as the concentration in vitro in hemolysis activity.