Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy

We reported a newly engineered photosensitizer of polymer encapsulated carbonized hemin nanoparticles (P-CHNPs) via a facile synthesis procedure for boosting photodynamic therapy (PDT). The synthesized P-CHNPs achieved enhanced oxidative stress in tumor microenvironment, which could be further amplified under light irradiation, enabling excellent in vitro and in vivo PDT effects. Moreover, the superior in vitro and in vivo biocompatibility and boosted PDT effect make the P-CHNPs a potential therapeutic agent for future translational research.