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Role of Carbon, Nitrogen, Phosphate and Sulfur Metabolism in Secondary Metabolism Precursor Supply in Streptomyces spp.

Authors :
Sergii Krysenko
Wolfgang Wohlleben
Source :
Microorganisms, Vol 12, Iss 8, p 1571 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The natural soil environment of Streptomyces is characterized by variations in the availability of nitrogen, carbon, phosphate and sulfur, leading to complex primary and secondary metabolisms. Their remarkable ability to adapt to fluctuating nutrient conditions is possible through the utilization of a large amount of substrates by diverse intracellular and extracellular enzymes. Thus, Streptomyces fulfill an important ecological role in soil environments, metabolizing the remains of other organisms. In order to survive under changing conditions in their natural habitats, they have the possibility to fall back on specialized enzymes to utilize diverse nutrients and supply compounds from primary metabolism as precursors for secondary metabolite production. We aimed to summarize the knowledge on the C-, N-, P- and S-metabolisms in the genus Streptomyces as a source of building blocks for the production of antibiotics and other relevant compounds.

Details

Language :
English
ISSN :
20762607
Volume :
12
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Microorganisms
Publication Type :
Academic Journal
Accession number :
edsdoj.252e4cf7cb1744a5a875a0e249a1fc91
Document Type :
article
Full Text :
https://doi.org/10.3390/microorganisms12081571