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Body Fat and Breast Cancer Risk in Postmenopausal Women: A Longitudinal Study

Authors :
Thomas E. Rohan
Moonseong Heo
Lydia Choi
Mridul Datta
Jo L. Freudenheim
Victor Kamensky
Heather M. Ochs-Balcom
Lihong Qi
Cynthia A. Thomson
Mara Z. Vitolins
Sylvia Wassertheil-Smoller
Geoffrey C. Kabat
Source :
Journal of Cancer Epidemiology, Vol 2013 (2013)
Publication Year :
2013
Publisher :
Hindawi Limited, 2013.

Abstract

Associations between anthropometric indices of obesity and breast cancer risk may fail to capture the true relationship between excess body fat and risk. We used dual-energy-X-ray-absorptiometry- (DXA-) derived measures of body fat obtained in the Women’s Health Initiative to examine the association between body fat and breast cancer risk; we compared these risk estimates with those for conventional anthropometric measurements. The study included 10,960 postmenopausal women aged 50–79 years at recruitment, with baseline DXA measurements and no history of breast cancer. During followup (median: 12.9 years), 503 incident breast cancer cases were diagnosed. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. All baseline DXA-derived body fat measures showed strong positive associations with breast cancer risk. The multivariable-adjusted HR for the uppermost quintile level (versus lowest) ranged from 1.53 (95% CI 1.14–2.07) for fat mass of the right leg to 2.05 (1.50–2.79) for fat mass of the trunk. Anthropometric indices (categorized by quintiles) of obesity (BMI (1.97, 1.45–2.68), waist circumference (1.97, 1.46–2.65), and waist : hip ratio (1.91, 1.41–2.58)) were all strongly, positively associated with risk and did not differ from DXA-derived measures in prediction of risk.

Subjects

Subjects :
Medicine

Details

Language :
English
ISSN :
16878558 and 16878566
Volume :
2013
Database :
Directory of Open Access Journals
Journal :
Journal of Cancer Epidemiology
Publication Type :
Academic Journal
Accession number :
edsdoj.254b3c75c6124567966357b6c9a59612
Document Type :
article
Full Text :
https://doi.org/10.1155/2013/754815