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Campylobacter jejuni virulence factors: update on emerging issues and trends

Campylobacter jejuni virulence factors: update on emerging issues and trends

Authors :
Alexandra Tikhomirova
Emmylee R. McNabb
Luca Petterlin
Georgia L. Bellamy
Kyaw H. Lin
Christopher A. Santoso
Ella S. Daye
Fatimah M. Alhaddad
Kah Peng Lee
Anna Roujeinikova
Source :
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-20 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Campylobacter jejuni is a very common cause of gastroenteritis, and is frequently transmitted to humans through contaminated food products or water. Importantly, C. jejuni infections have a range of short- and long-term sequelae such as irritable bowel syndrome and Guillain Barre syndrome. C. jejuni triggers disease by employing a range of molecular strategies which enable it to colonise the gut, invade the epithelium, persist intracellularly and avoid detection by the host immune response. The objective of this review is to explore and summarise recent advances in the understanding of the C. jejuni molecular factors involved in colonisation, invasion of cells, collective quorum sensing-mediated behaviours and persistence. Understanding the mechanisms that underpin the pathogenicity of C. jejuni will enable future development of effective preventative approaches and vaccines against this pathogen.

Details

Language :
English
ISSN :
14230127
Volume :
31
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Biomedical Science
Publication Type :
Academic Journal
Accession number :
edsdoj.25ab43b35c454493a85517ac2e1abf2d
Document Type :
article
Full Text :
https://doi.org/10.1186/s12929-024-01033-6