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Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study

Authors :
Sahar Gamil
Jeanette Erdmann
Ihab B. Abdalrahman
Abdelrahim O. Mohamed
Source :
BMC Medical Genetics, Vol 18, Iss 1, Pp 1-9 (2017)
Publication Year :
2017
Publisher :
BMC, 2017.

Abstract

Abstract Background Essential hypertension (EH) is influenced by various environmental and genetic factors. Nitric oxide is important for the functional integrity of the vascular endothelium and is produced in endothelial cells by the enzyme endothelial nitric oxide synthase (eNOS). EH has a strong genetic component, and the NOS3 gene, which encodes eNOS, represents an interesting candidate for contribution to the phenotype. The most clinically relevant polymorphisms in the NOS3 gene are rs1799983 in exon 7 (encoding Glu298Asp), a variable number tandem repeat (VNTR) in intron 4, and rs2070744 (T-786C) in the promoter region. This study aims to investigate the association between these three polymorphisms in the NOS3 gene and EH in Sudanese patients. Methods Hypertensive patients (n = 157) > 18 years of age with established hypertension from various hospitals in Khartoum, and controls (n = 85) > 18 years of age and with blood pressure measurements 1% of the Sudanese population under study. Conclusion The results of this study indicated that the rs2070744 polymorphism in NOS3 may be a genetic susceptibility factor for EH in the Sudanese population. The c allele of intron 4 VNTR is not rare in the Sudanese population.

Details

Language :
English
ISSN :
14712350
Volume :
18
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Medical Genetics
Publication Type :
Academic Journal
Accession number :
edsdoj.25c941ee42d44593bf78f8ee8f8a14a9
Document Type :
article
Full Text :
https://doi.org/10.1186/s12881-017-0491-7