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Neurotrophic factors and their inhibitors in chronic pain treatment
- Source :
- Neurobiology of Disease, Vol 97, Iss , Pp 127-138 (2017)
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.
Details
- Language :
- English
- ISSN :
- 1095953X
- Volume :
- 97
- Issue :
- 127-138
- Database :
- Directory of Open Access Journals
- Journal :
- Neurobiology of Disease
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.25d8448acfa048e4821524852182c72d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.nbd.2016.03.025