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Psoriasis and Genetics

Authors :
Nick Dand
Satveer K. Mahil
Francesca Capon
Catherine H. Smith
Michael A. Simpson
Jonathan N. Barker
Source :
Acta Dermato-Venereologica, Vol 100, Iss 3, p adv00030 (2020)
Publication Year :
2020
Publisher :
Medical Journals Sweden, 2020.

Abstract

Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent progress in elucidating the genetic basis of psoriasis, particularly through large genome-wide association studies. We illustrate the power of genetic analyses for disease stratification. Psoriasis can be stratified by phenotype (common plaque versus rare pustular variants), or by outcome (prognosis, comorbidities, response to treatment); recent progress has been made in delineating the genetic contribution in each of these areas. We also highlight how genetic data can directly inform the development of effective psoriasis treatments.

Details

Language :
English
ISSN :
00015555 and 16512057
Volume :
100
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Acta Dermato-Venereologica
Publication Type :
Academic Journal
Accession number :
edsdoj.260bfd24c4f644ca9ce68dc27be11a64
Document Type :
article
Full Text :
https://doi.org/10.2340/00015555-3384