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Influence of bushenhuoxue on primary visual cortex' BDNF damage in rat model of chronic elevated intraocular pressure
- Source :
- Guoji Yanke Zazhi, Vol 13, Iss 4, Pp 647-651 (2013)
- Publication Year :
- 2013
- Publisher :
- Press of International Journal of Ophthalmology (IJO PRESS), 2013.
-
Abstract
- AIM: To observe the effect of traditional Chinese medicine(TCM)of bushenhuoxue on primary visual cortex(PVC)brain-derived neurotrophic factor(BDNF)in rat model of chronic elevated intraocular pressure(EIOP), and explore the mechanism of it initially. METHODS: The rat model of chronic EIOP was established by unilaterally cauterizing 3 episcleral veins, then 30 rats were divided into 3 groups randomly: control group, model group, and treatment group. After given drugs or normal saline for 8 weeks, the rats were put to death. The effect of intraocular pressure(IOP), expression of BDNF and ultrastructure of neuron cell in the PVC was observed. RESULTS: Unilaterally cauterizing episcleral veins increased IOP of the rat model obviously, there was significant difference compared with pre-operation(P
Details
- Language :
- English
- ISSN :
- 16725123
- Volume :
- 13
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Guoji Yanke Zazhi
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.261147f2ff9d499d9330a7d0b6d2ce30
- Document Type :
- article
- Full Text :
- https://doi.org/10.3980/j.issn.1672-5123.2013.04.01