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Long non-coding RNA AL137789.1 promoted malignant biological behaviors and immune escape of pancreatic carcinoma cells

Authors :
Wang Jing
Shen Yiyu
Wang Xiaoguang
Zhou Zhongcheng
Zhong Zhengxiang
Gu Tianyuan
Wu Bin
Source :
Open Medicine, Vol 18, Iss 1, Pp 6572-89 (2023)
Publication Year :
2023
Publisher :
De Gruyter, 2023.

Abstract

Our pre-investigation has revealed that long non-coding RNA (LncRNA) AL137789.1 has the potential to predict the survival of patients with pancreatic carcinoma (PCa). Accordingly, the mechanism underlying the implication of AL137789.1 in PCa is covered in the current study. The non-tumor and paired tumor tissues were collected. Kaplan–Meier curve was employed to estimate the survival of PCa patients with high or low expression of AL137789.1. The proliferation, migration, invasion, and cell cycle of PCa cells were determined, and the cytotoxicity of CD8+ T cells was evaluated as well. Levels of AL137789.1, E-cadherin, N-cadherin, and Vimentin were quantified. According to the experimental results, AL137789.1 was highly expressed in PCa and related to a poor prognosis of patients. Overexpressed AL137789.1 enhanced the proliferation, migration, and invasion of PCa cells, increased the cell population at G2/M and S phases yet decreased that in G0/G1 phase, and diminished the cytotoxicity of CD8+ T cells. Also, overexpressed AL137789.1 elevated levels of N-cadherin and Vimentin, while lessening E-cadherin levels. However, the silencing of AL137789.1 produced contrary effects. Collectively, lncRNA AL137789.1 plays a tumor-promotive role in PCa by enhancing the progression and immune escape.

Details

Language :
English
ISSN :
23915463
Volume :
18
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Open Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.266f7394d5c44bc980d4a1d1e02cc221
Document Type :
article
Full Text :
https://doi.org/10.1515/med-2023-0661