Evaluation of risk factors and modern possibilities for prediction of preterm labour

The aim is based on the comprehensive examination of pregnant women to determine the risk factors for preterm labor and develop criteria for its prediction.Materials and methods. In a prospective opened study took part 63 patients at 22–34 weeks of gestation. The study was carried out on the basis of PI “Regional Perinatal Center” ZRC, which is the clinical base of the Department of Obstetrics and Gynecology, ZSMU. The average age of pregnant women was 27.1 ± 0.8 (M ± SD) years. Pregnant women were divided into two groups, depending on the gestation period course. Thus, group I included 44 pregnant women who had TPL (threatened preterm labor), and group II – 19 patients with normal course of pregnancy.In the first day, body mass index was determined and laboratory examinations (progesterone, insulin and cortisol level) were performed.Results. According to the ROC analysis, we obtained the following distribution points: the age of pregnant women over 35 years (sensitivity 33.3 %, specificity 96.1 %), the area under the ROC curve of 0.542 (95 % CI 0.411–0.668, P = 0.6953); body mass index (BMI) ≤22.95 kg/m² (sensitivity 66.7 %, specificity 84.3 %), the area under the ROC curve 0.694 (95 % CI 0.566–0.804, P = 0.01); insulin >31.36 μMe/ml (sensitivity 41.7 %, specificity 90.2 %), the area under the ROC curve 0.505 (95 % CI 0.376–0.633, P = 0.96); cortisol ≤609.7 ng/ml (75 % sensitivity, 55 % specificity), the area under the ROC curve of 0.694 (95 % CI 0.518–0.765, P = 0.07); progesterone