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Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening

Authors :
Marie Miglianico
Judith M. Bolscher
Martijn W. Vos
Karin J. M. Koolen
Marloes de Bruijni
Deeya S. Rajagopal
Emily Chen
Michael Kiczun
David Gray
Brice Campo
Robert W. Sauerwein
Koen J. Dechering
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

A high-throughput screening pipeline tests the feasibility of targeting the sporozoite stage of P. falciparum through chemical interventions and identifies gramicidin as a potential sporontocidal agent.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.274c968724b1436f997a2540094cde1f
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04599-3