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Bridging Targeted and Untargeted Mass Spectrometry-Based Metabolomics via Hybrid Approaches

Bridging Targeted and Untargeted Mass Spectrometry-Based Metabolomics via Hybrid Approaches

Authors :
Li Chen
Fanyi Zhong
Jiangjiang Zhu
Source :
Metabolites, Vol 10, Iss 9, p 348 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

This mini-review aims to discuss the development and applications of mass spectrometry (MS)-based hybrid approaches in metabolomics. Several recently developed hybrid approaches are introduced. Then, the overall workflow, frequently used instruments, data handling strategies, and applications are compared and their pros and cons are summarized. Overall, the improved repeatability and quantitative capability in large-scale MS-based metabolomics studies are demonstrated, in comparison to either targeted or untargeted metabolomics approaches alone. In summary, we expect this review to serve as a first attempt to highlight the development and applications of emerging hybrid approaches in metabolomics, and we believe that hybrid metabolomics approaches could have great potential in many future studies.

Details

Language :
English
ISSN :
22181989
Volume :
10
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Metabolites
Publication Type :
Academic Journal
Accession number :
edsdoj.27f550c77bcf4bc6a5ed5fe1ca217cf0
Document Type :
article
Full Text :
https://doi.org/10.3390/metabo10090348