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Airway inflammation in patients with bronchiectasis

Authors :
Đurđević Nataša
Milenković Branislava
Janković Jelena
Mitić Javorka
Belić Slobodan
Jordanova Elena
Baralić Marko
Source :
Halo 194, Vol 27, Iss 2, Pp 68-72 (2021)
Publication Year :
2021
Publisher :
City Medical emergency department, Belgrade, 2021.

Abstract

Bronchiectasis is a chronic lung disease characterized by an abnormal dilation of the bronchial lumen caused by weakening or destruction of the muscle or elastic components of the bronchial wall, decreased mucous clearance and frequent infections of the respiratory tract. The golden standard for bronchiectasis diagnosis is high-resolution computed tomography (HRCT) of the chest. Inflammation holds a central role in the development of structural lung changes, as well as airway and lung parenchyma damage. Infection and colonization of the respiratory tract contribute to increased inflammation and further damage to the lung. Upon entry into the respiratory tract, the pathogens activate epithelial cells, macrophages and dendritic cells. Activated inflammatory cells secrete chemical mediators which activate the immune response and thus allow the phagocytosis of pathogens. Early diagnosis, appropriate treatment and interruption of the vicious circle between infection and inflammation in patients suffering from bronchiectasis, prevent the development of structural changes to the airways.

Details

Language :
English, Serbian
ISSN :
23346477
Volume :
27
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Halo 194
Publication Type :
Academic Journal
Accession number :
edsdoj.285d8990938e4820bebf2080b683fdec
Document Type :
article
Full Text :
https://doi.org/10.5937/halo27-31410