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Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial

Authors :
Amit X. Garg
Meaghan Cuerden
Hector Aguado
Mohammed Amir
Emilie P. Belley-Cote
Keyur Bhatt
Bruce M. Biccard
Flavia K. Borges
Matthew Chan
David Conen
Emmanuelle Duceppe
Sergey Efremov
John Eikelboom
Edith Fleischmann
Landoni Giovanni
Peter Gross
Raja Jayaram
Mikhail Kirov
Ydo Kleinlugtenbelt
Andrea Kurz
Andre Lamy
Kate Leslie
Valery Likhvantsev
Vladimir Lomivorotov
Maura Marcucci
Maria José Martínez-Zapata
Michael McGillion
William McIntyre
Christian Meyhoff
Sandra Ofori
Thomas Painter
Pilar Paniagua
Chirag Parikh
Joel Parlow
Ameen Patel
Carisi Polanczyk
Toby Richards
Pavel Roshanov
Denis Schmartz
Daniel Sessler
Tim Short
Jessica M. Sontrop
Jessica Spence
Sadeesh Srinathan
David Stillo
Wojciech Szczeklik
Vikas Tandon
David Torres
Thomas Van Helder
Jessica Vincent
C. Y. Wang
Michael Wang
Richard Whitlock
Maria Wittmann
Denis Xavier
P. J. Devereaux
Source :
Canadian Journal of Kidney Health and Disease, Vol 9 (2022)
Publication Year :
2022
Publisher :
SAGE Publishing, 2022.

Abstract

Background: Most patients who take antihypertensive medications continue taking them on the morning of surgery and during the perioperative period. However, growing evidence suggests this practice may contribute to perioperative hypotension and a higher risk of complications. This protocol describes an acute kidney injury substudy of the Perioperative Ischemic Evaluation-3 (POISE-3) trial, which is testing the effect of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy in patients undergoing noncardiac surgery. Objective: To conduct a substudy of POISE-3 to determine whether a perioperative hypotension-avoidance strategy reduces the risk of acute kidney injury compared with a hypertension-avoidance strategy. Design: Randomized clinical trial with 1:1 randomization to the intervention (a perioperative hypotension-avoidance strategy) or control (a hypertension-avoidance strategy). Intervention: If the presurgery systolic blood pressure (SBP) is

Details

Language :
English
ISSN :
20543581
Volume :
9
Database :
Directory of Open Access Journals
Journal :
Canadian Journal of Kidney Health and Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.286d30fb9124fbd9fcbfc3c9ed5ff9e
Document Type :
article
Full Text :
https://doi.org/10.1177/20543581211069225