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Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial
- Source :
- Canadian Journal of Kidney Health and Disease, Vol 9 (2022)
- Publication Year :
- 2022
- Publisher :
- SAGE Publishing, 2022.
-
Abstract
- Background: Most patients who take antihypertensive medications continue taking them on the morning of surgery and during the perioperative period. However, growing evidence suggests this practice may contribute to perioperative hypotension and a higher risk of complications. This protocol describes an acute kidney injury substudy of the Perioperative Ischemic Evaluation-3 (POISE-3) trial, which is testing the effect of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy in patients undergoing noncardiac surgery. Objective: To conduct a substudy of POISE-3 to determine whether a perioperative hypotension-avoidance strategy reduces the risk of acute kidney injury compared with a hypertension-avoidance strategy. Design: Randomized clinical trial with 1:1 randomization to the intervention (a perioperative hypotension-avoidance strategy) or control (a hypertension-avoidance strategy). Intervention: If the presurgery systolic blood pressure (SBP) is
- Subjects :
- Diseases of the genitourinary system. Urology
RC870-923
Subjects
Details
- Language :
- English
- ISSN :
- 20543581
- Volume :
- 9
- Database :
- Directory of Open Access Journals
- Journal :
- Canadian Journal of Kidney Health and Disease
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.286d30fb9124fbd9fcbfc3c9ed5ff9e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1177/20543581211069225