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A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure

Authors :
Hélène Choquet
Khanh K. Thai
Jie Yin
Thomas J. Hoffmann
Mark N. Kvale
Yambazi Banda
Catherine Schaefer
Neil Risch
K. Saidas Nair
Ronald Melles
Eric Jorgenson
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Intraocular pressure (IOP) is a major risk factor for glaucoma. Here, Choquet and co-authors perform a multi-ethnic genome-wide association study of repeat IOP measurements in 69,756 individuals and identify 40 novel loci, 36 of which show directionally consistent effects in glaucoma.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.28f9a2d6c08476a9173b4a2e8409689
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-01913-6