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MNDA expression and its value in differential diagnosis of B-cell non-Hodgkin lymphomas: a comprehensive analysis of a large series of 1293 cases

MNDA expression and its value in differential diagnosis of B-cell non-Hodgkin lymphomas: a comprehensive analysis of a large series of 1293 cases

Authors :
Li-Fen Zhang
Yan Zhang
Rou-Hong Shui
Hong-Fen Lu
Wen-Hua Jiang
Xu Cai
Xiao-Qiu Li
Bao-Hua Yu
Source :
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-10 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Aims MNDA (myeloid nuclear differentiation antigen) has been considered as a potential diagnostic marker for marginal zone lymphoma (MZL), but its utility in distinguishing MZL from other B-cell non-Hodgkin lymphomas (B-NHLs) and its clinicopathologic relevance in diffuse large B-cell lymphoma (DLBCL) are ambiguous. We comprehensively investigated MNDA expression in a large series of B-NHLs and evaluated its diagnostic value. Methods MNDA expression in a cohort of 1293 cases of B-NHLs and 338 cases of reactive lymphoid hyperplasia (RLH) was determined using immunohistochemistry and compared among different types of B-NHL. The clinicopathologic relevance of MNDA in DLBCL was investigated. Results MNDA was highly expressed in MZLs (437/663, 65.9%), compared with the confined staining in marginal zone B-cells in RLH; whereas neoplastic cells with plasmacytic differentiation lost MNDA expression. MNDA expression was significantly higher in mantle cell lymphoma (MCL, 79.6%, p = 0.006), whereas lower in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL, 44.8%, p = 0.001) and lymphoplasmacytic lymphoma (LPL, 25%, p = 0.016), and dramatically lower in follicular lymphoma (FL, 5.2%, p

Details

Language :
English
ISSN :
17461596
Volume :
19
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Diagnostic Pathology
Publication Type :
Academic Journal
Accession number :
edsdoj.2901fd0c39c1464ea1fefc4fc5d789ee
Document Type :
article
Full Text :
https://doi.org/10.1186/s13000-024-01481-6