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Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria

Authors :
Huan Yang
Caroline Sibilla
Raymond Liu
Jina Yun
Bruce A. Hay
Craig Blackstone
David C. Chan
Robert J. Harvey
Ming Guo
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Drp1 is the master regulator of mitochondrial fission, which has important impact on cellular functions. Here, Yang et al identified evolutionarily conserved proteins Clueless and its homolog CLUH as key regulators of Drp1 that function via translation of Drp1 receptors MiD49 and Mff.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.295bcd55fca249279a87c90de815fa7a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-29071-4