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Association of serum brain‐derived neurotrophic factor level and early response to antipsychotic drug in first‐episode patients with schizophrenia

Authors :
Tong Zhao
SuFang Tang
XiaoLei Gao
Juan Li
Ran Hao
HaiZhi Chen
GuangBiao Huang
Source :
International Journal of Methods in Psychiatric Research, Vol 33, Iss 1, Pp n/a-n/a (2024)
Publication Year :
2024
Publisher :
Wiley, 2024.

Abstract

Abstract Objectives To investigate the role of Brain derived neurotrophic factor (BDNF) in the psychotic symptoms in first‐episode patients with schizophrenia and whether BDNF levels were associated with the improvement of psychotic symptoms after risperidone treatment. Methods 89 schizophrenia patients and 90 healthy controls were recruited, the schizophrenia patients were assigned into early response or early non‐response groups at 2 weeks based on improvement in the positive and negative symptoms scale (PANSS) total score. All patients were treated with risperidone for 2 weeks, their serum BDNF levels were compared at baseline and after 2 weeks treatment. Results We found that patients had lower BDNF levels, compared to controls at baseline. After 2 weeks of treatment of risperidone, BDNF levels were significantly increased and psychotic symptoms were decreased in early response group. Correlation analysis showed that the change of BDNF levels after treatment was correlated with the change of PANSS total score. Further regression analysis showed that the change in BDNF levels was an independent predictor for the improvement in psychotic symptoms. Conclusions Our findings reveal that the level of BDNF was lower in first‐episode schizophrenic patients, moreover, the changes in serum BDNF levels may have a predictive effect on the early improvement in psychotic symptoms in the first 2 weeks.

Details

Language :
English
ISSN :
15570657 and 10498931
Volume :
33
Issue :
1
Database :
Directory of Open Access Journals
Journal :
International Journal of Methods in Psychiatric Research
Publication Type :
Academic Journal
Accession number :
edsdoj.2981ff48bf1e4b5c8b0a3c9a7bf391c0
Document Type :
article
Full Text :
https://doi.org/10.1002/mpr.1982