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Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches
- Source :
- International Journal of Molecular Sciences, Vol 18, Iss 6, p 1145 (2017)
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- Most intracellular proteins are subjected to post-translational modification by ubiquitin. Accordingly, it is of fundamental importance to investigate the biological and physicochemical effects of ubiquitylation on substrate proteins. However, preparation of ubiquitylated proteins by an enzymatic synthesis bears limitations in terms of yield and site-specificity. Recently established chemical ubiquitylation methodologies can overcome these problems and provide a new understanding of ubiquitylation. Herein we describe the recent chemical ubiquitylation procedures with a focus on the effects of ubiquitylation on target proteins revealed by the synthetic approach.
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 18
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.29c5f2b6cd42495bb9b5ae8c4117059c
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/ijms18061145