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A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- The MET receptor is frequently activated in cancer. Here, the authors show that in head and neck and lung squamous carcinoma, a polymorphic MET variant enhances binding to HER2, resulting in activation of HER2 signalling and progression of the cancers.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.29d0a642abdc45549ef07f126485d155
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-15318-5