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Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy

Authors :
Abhinay Gontu
Sreenidhi Srinivasan
Eric Salazar
Meera Surendran Nair
Ruth H. Nissly
Denver Greenawalt
Ian M. Bird
Catherine M. Herzog
Matthew J. Ferrari
Indira Poojary
Robab Katani
Scott E. Lindner
Allen M. Minns
Randall Rossi
Paul A. Christensen
Brian Castillo
Jian Chen
Todd N. Eagar
Xin Yi
Picheng Zhao
Christopher Leveque
Randall J. Olsen
David W. Bernard
Jimmy Gollihar
Suresh V. Kuchipudi
James M. Musser
Vivek Kapur
Source :
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Gontu et al. conducted a longitudinal study in COVID patients in which they assessed the response trajectories of antibodies directed to the SARS-CoV-2 surface spike glycoprotein and in vitro SARS-CoV-2 live virus neutralizing titers. Their measurements demonstrate the presence of an optimum window for convalescent plasma donation as well as predictions of the most suitable donor type.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
4
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.29e9d16320ed452bba1c23cd05a61b50
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-021-01813-y