Accelerated biological aging mediates the association between inflammatory markers with Helicobacter pylori infection and mortality

Abstract Background The aim of this study was to explore the systemic inflammation response in relation to mortality in Helicobacter pylori (H. pylori) infection, and whether this relationship was mediated by accelerated biological aging. Methods This cross-sectional study encompassed U.S. participants from National Health and Nutrition Examination Survey (NHANES) in 1999–2000. Kaplan-Meier survival curve, Cox regression analysis, K-means clustering, mediation analysis and restricted cubic spline (RCS) were used to explore the relationships between inflammatory markers, biological aging, H. pylori infection and all-cause mortality. Results A total of 3509 U.S. participants enrolled form NHANES 1999–2000. Compared with H. pylori seronegative participants, H. pylori seropositive participants had significantly higher all-cause mortality (P