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The Effect of Cysteine Peptide Ingestion on Skin Brightness, a Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Human Clinical Trial

Authors :
Yoshiaki Uchida
Tomomi Kaneda
Mio Ono
Masao Matsuoka
Utano Nakamura
Akiko Ishida
Yoshimitsu Yamasaki
Hiroki Takeo
Takanobu Sakurai
Source :
Cosmetics, Vol 10, Iss 3, p 72 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Glutathione (GSH) is present in almost all human cells and has a beneficial effect on human skin brightness. Cysteinylglycine (Cys-Gly) and γ-glutamylcysteine (γ-Glu-Cys) are GSH synthesis components. In this study, we defined glutathione (GSH), cysteinylglycine (Cys-Gly), and γ-glutamylcysteine (γ-Glu-Cys) as cysteine peptide and performed a randomized, double-blind, placebo-controlled study to investigate the effects of orally administered cysteine peptide on human skin brightness using a CM-26d portable spectrophotometer in healthy males and females aged between 20 and 65 years old. Eligible participants were randomly allocated into three groups (cysteine peptide 45 mg: n = 16, 90 mg: n = 15, and placebo: n = 16). Each subject ingested six tablets every day for 12 weeks, and skin brightness was measured at 0, 4, 8, and 12 weeks. As a result, the 45 mg group exhibited arm brightening in a time-dependent manner, and a significant difference was observed compared to the placebo at week 12 (p = 0.028). Moreover, no serious adverse events and changes related to 270 mg study food were observed in the safety trial. Here, we suggest that cysteine peptide is a promising and safe compound for human skin brightness.

Details

Language :
English
ISSN :
20799284
Volume :
10
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Cosmetics
Publication Type :
Academic Journal
Accession number :
edsdoj.2a2fed47d7a845d9838f1f7b863c895b
Document Type :
article
Full Text :
https://doi.org/10.3390/cosmetics10030072