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Tamoxifen Delivery System Based on PEGylated Magnetic MCM-41 Silica

Authors :
Margarita Popova
Neli Koseva
Ivalina Trendafilova
Hristina Lazarova
Violeta Mitova
Judith Mihály
Denitsa Momekova
Georgi Momekov
Iskra Z. Koleva
Hristiyan A. Aleksandrov
Georgi N. Vayssilov
Ágnes Szegedi
Source :
Molecules, Vol 25, Iss 21, p 5129 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Magnetic iron oxide containing MCM-41 silica (MM) with ~300 nm particle size was developed. The MM material before or after template removal was modified with NH2- or COOH-groups and then grafted with PEG chains. The anticancer drug tamoxifen was loaded into the organic groups’ modified and PEGylated nanoparticles by an incipient wetness impregnation procedure. The amount of loaded drug and the release properties depend on whether modification of the nanoparticles was performed before or after the template removal step. The parent and drug-loaded samples were characterized by XRD, N2 physisorption, thermal gravimetric analysis, and ATR FT-IR spectroscopy. ATR FT-IR spectroscopic data and density functional theory (DFT) calculations supported the interaction between the mesoporous silica surface and tamoxifen molecules and pointed out that the drug molecule interacts more strongly with the silicate surface terminated by silanol groups than with the surface modified with carboxyl groups. A sustained tamoxifen release profile was obtained by an in vitro experiment at pH = 7.0 for the PEGylated formulation modified by COOH groups after the template removal. Free drug and formulated tamoxifen samples were further investigated for antiproliferative activity against MCF-7 cells.

Details

Language :
English
ISSN :
14203049
Volume :
25
Issue :
21
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.2a342b8c48bb4be999e1e5c724049d5d
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules25215129