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Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential

Authors :
Sabrin R. M. Ibrahim
Sana A. Fadil
Haifa A. Fadil
Bayan A. Eshmawi
Shaimaa G. A. Mohamed
Gamal A. Mohamed
Source :
Toxins, Vol 14, Iss 2, p 154 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Fungi are well-known for their abundant supply of metabolites with unrivaled structure and promising bioactivities. Naphthalenones are among these fungal metabolites, that are biosynthesized through the 1,8-dihydroxy-naphthalene polyketide pathway. They revealed a wide spectrum of bioactivities, including phytotoxic, neuro-protective, cytotoxic, antiviral, nematocidal, antimycobacterial, antimalarial, antimicrobial, and anti-inflammatory. The current review emphasizes the reported naphthalenone derivatives produced by various fungal species, including their sources, structures, biosynthesis, and bioactivities in the period from 1972 to 2021. Overall, more than 167 references with 159 metabolites are listed.

Details

Language :
English
ISSN :
20726651
Volume :
14
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Toxins
Publication Type :
Academic Journal
Accession number :
edsdoj.2a35607ce164902989dcf6973c3bf71
Document Type :
article
Full Text :
https://doi.org/10.3390/toxins14020154