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Secondary Metabolites with Antioxidant and Antimicrobial Activities from Camellia fascicularis

Authors :
Jiandong Tang
Ruonan Li
Boxiao Wu
Junrong Tang
Huan Kan
Ping Zhao
Yingjun Zhang
Weihua Wang
Yun Liu
Source :
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 6769-6782 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Camellia fascicularis has important ornamental, medicinal, and food value. It also has tremendous potential for exploiting bioactivities. However, the bioactivities of secondary metabolites in C. fascicularis have not been reported. The structures of compounds were determined by spectral analysis and nuclear magnetic resonance (NMR) combined with the available literature on secondary metabolites of C. fascicularis leaves. In this study, 15 compounds were identified, including 5 flavonoids (1–5), a galactosylglycerol derivative (6), a terpenoid (7), 4 lignans (8–11), and 4 phenolic acids (12–15). Compounds 6–7 and 9–12 were isolated from the genus Camellia for the first time. The remaining compounds were also isolated from C. fascicularis for the first time. Evaluation of antioxidant and antimicrobial activities revealed that compounds 5 and 8–11 exhibited stronger antioxidant activity than the positive drug ascorbic acid, while compounds 7, 13, and 15 showed similar activity to ascorbic acid. The minimum inhibitory concentration (MIC) of antibacterial activity for compounds 5, 7, 9, 11, and 13 against Pseudomonas aeruginosa was comparable to that of the positive control drug tetracycline at a concentration of 62.50 µg/mL; other secondary metabolites inhibited Escherichia coli and Staphylococcus aureus at concentrations ranging from 125–250 µg/mL.

Details

Language :
English
ISSN :
14673045 and 14673037
Volume :
46
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Current Issues in Molecular Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.2ae3fe6013fd42529ac7ee19445c6b06
Document Type :
article
Full Text :
https://doi.org/10.3390/cimb46070404