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An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

Authors :
Keiko Kawauchi
Wataru Sugimoto
Takatoshi Yasui
Kohei Murata
Katsuhiko Itoh
Kazuki Takagi
Takaaki Tsuruoka
Kensuke Akamatsu
Hisae Tateishi-Karimata
Naoki Sugimoto
Daisuke Miyoshi
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2b986b81e324fa785914b0394c35e22
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-04771-y